Internship position
The Penninger Lab at IMBA is looking for a motivated student for an internship position to aid in a
disease-oriented, patient-based stem cell & organoid project over the course of 5 months.
Project description
The blood vessel organoid system developed in our lab has been successfully used to model and
interrogate the pathological mechanisms behind diabetic vasculopathy in vitro1,2. This project now aims
to apply this organoid system to characterize the genetic vascular disorder “CADASIL” (Cerebral
Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy). The intern
will be involved in the maintenance, differentiation and analysis of patient-derived stem cells and the
therefrom derived vascular organoids.
Methods
- Human stem cell culture (iPSC and ESC)
- Stem cell differentiation
- Blood vessel organoid generation and analysis
Requirements
Highly organized and motivated student with profound experience in human cell culture. Experience
with human stem cells highly preferred. Work with organoids will be performed, but previous
experience is not a requirement.
Deadline of application
June 14th, 2023
Contact for application:
kirill.salewskij@imba.oeaw.ac.at
1. Wimmer RA, Leopoldi A, Aichinger M, et al. Human blood vessel organoids as a model of diabetic vasculopathy. Nature. 2019;565(7740):505-510.
2. Salewskij K, Penninger JM. Blood Vessel Organoids for Development and Disease. Circ Res. 2023;132(4):498-510.
